Ontology highlight
ABSTRACT:
SUBMITTER: Sher YP
PROVIDER: S-EPMC3976390 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Sher Yuh-Pyng YP Wang Li-Ju LJ Chuang Li-Ling LL Tsai Mong-Hsun MH Kuo Ting-Ting TT Huang Cheng-Chung CC Chuang Eric Y EY Lai Liang-Chuan LC
PloS one 20140404 4
Lung cancer is the leading cause of cancer death worldwide, and brain metastasis is a major cause of morbidity and mortality in lung cancer. CDH2 (N-cadherin, a mesenchymal marker of the epithelial-mesenchymal transition) and ADAM9 (a type I transmembrane protein) are related to lung cancer brain metastasis; however, it is unclear how they interact to mediate this metastasis. Because microRNAs regulate many biological functions and disease processes (e.g., cancer) by down-regulating their target ...[more]