Ontology highlight
ABSTRACT:
SUBMITTER: Miron VE
PROVIDER: S-EPMC3977045 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Miron Veronique E VE Boyd Amanda A Zhao Jing-Wei JW Yuen Tracy J TJ Ruckh Julia M JM Shadrach Jennifer L JL van Wijngaarden Peter P Wagers Amy J AJ Williams Anna A Franklin Robin J M RJM Ffrench-Constant Charles C
Nature neuroscience 20130721 9
The lack of therapies for progressive multiple sclerosis highlights the need to understand the regenerative process of remyelination that can follow CNS demyelination. This involves an innate immune response consisting of microglia and macrophages, which can be polarized to distinct functional phenotypes: pro-inflammatory (M1) and anti-inflammatory or immunoregulatory (M2). We found that a switch from an M1- to an M2-dominant response occurred in microglia and peripherally derived macrophages as ...[more]