Ontology highlight
ABSTRACT:
SUBMITTER: Dai X
PROVIDER: S-EPMC3977114 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Dai Xiaoyu X Wang Chao C Dai Jin J Shi Dongquan D Xu Zhihong Z Chen Dongyang D Teng Huajian H Jiang Qing Q
BioMed research international 20140317
Osteoarthritis (OA) is the most prevalent form of arthritis and its multifactorial nature has been increasingly recognized. Genetic factors play an important role in OA etiology and estrogen receptor alpha (ESR1) gene polymorphisms may be involved. This study tried to explore whether the ESR1 gene single nucleotide polymorphisms (SNPs) were associated with primary knee OA in the Chinese Han population. Two SNPs, rs2234693 and rs9340799, were genotyped in 469 cases and 522 controls. Rs2234693 was ...[more]