Phosphoprotein secretome of tumor cells as a source of candidates for breast cancer biomarkers in plasma.

ABSTRACT: Breast cancer is a heterogeneous disease whose molecular diversity is not well reflected in clinical and pathological markers used for prognosis and treatment selection. As tumor cells secrete proteins into the extracellular environment, some of these proteins reach circulation and could become suitable biomarkers for improving diagnosis or monitoring response to treatment. As many signaling pathways and interaction networks are altered in cancerous tissues by protein phosphorylation, changes in the secretory phosphoproteome of cancer tissues could reflect both disease progression and subtype. To test this hypothesis, we compared the phosphopeptide-enriched fractions obtained from proteins secreted into conditioned media (CM) derived from five luminal and five basal type breast cancer cell

SUBMITTER: Zawadzka AM 

PROVIDER: S-EPMC3977182 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature