Ontology highlight
ABSTRACT:
SUBMITTER: Howe AC
PROVIDER: S-EPMC3977251 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Howe Adina Chuang AC Jansson Janet K JK Malfatti Stephanie A SA Tringe Susannah G SG Tiedje James M JM Brown C Titus CT
Proceedings of the National Academy of Sciences of the United States of America 20140314 13
The large volumes of sequencing data required to sample deeply the microbial communities of complex environments pose new challenges to sequence analysis. De novo metagenomic assembly effectively reduces the total amount of data to be analyzed but requires substantial computational resources. We combine two preassembly filtering approaches--digital normalization and partitioning--to generate previously intractable large metagenome assemblies. Using a human-gut mock community dataset, we demonstr ...[more]