Ontology highlight
ABSTRACT:
SUBMITTER: Song G
PROVIDER: S-EPMC3977308 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Song Gaojie G Springer Timothy A TA
Proceedings of the National Academy of Sciences of the United States of America 20140317 13
Micronemal protein 2 (MIC2) is the key adhesin that supports gliding motility and host cell invasion by Toxoplasma gondii. With a von Willebrand factor A (VWA) domain and six thrombospondin repeat domains (TSR1-6) in its ectodomain, MIC2 connects to the parasite actomyosin system through its cytoplasmic tail. MIC2-associated protein (M2AP) binds noncovalently to the MIC2 ectodomain. MIC2 and M2AP are stored in micronemes as proforms. We find that the MIC2-M2AP ectodomain complex is a highly elon ...[more]