Ontology highlight
ABSTRACT:
SUBMITTER: Wolkowicz UM
PROVIDER: S-EPMC3977574 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Wolkowicz Urszula M UM Morris Elizabeth R ER Robson Michael M Trubitsyna Maryia M Richardson Julia M JM
ACS chemical biology 20140110 3
DNA transposases catalyze the movement of transposons around genomes by a cut-and-paste mechanism related to retroviral integration. Transposases and retroviral integrases share a common RNaseH-like domain with a catalytic DDE/D triad that coordinates the divalent cations required for DNA cleavage and integration. The anti-retroviral drugs Raltegravir and Elvitegravir inhibit integrases by displacing viral DNA ends from the catalytic metal ions. We demonstrate that Raltegravir, but not Elvitegra ...[more]