Galactaro ?-lactone isomerase: lactone isomerization by a member of the amidohydrolase superfamily.
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ABSTRACT:
SUBMITTER: Bouvier JT
PROVIDER: S-EPMC3977579 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
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Galactaro δ-lactone isomerase: lactone isomerization by a member of the amidohydrolase superfamily.
Bouvier Jason T JT Groninger-Poe Fiona P FP Vetting Matthew M Almo Steven C SC Gerlt John A JA
Biochemistry 20140124 4
Agrobacterium tumefaciens strain C58 can utilize d-galacturonate as a sole source of carbon via a pathway in which the first step is oxidation of d-galacturonate to D-galactaro-1,5-lactone. We have identified a novel enzyme, D-galactarolactone isomerase (GLI), that catalyzes the isomerizaton of D-galactaro-1,5-lactone to D-galactaro-1,4-lactone. GLI, a member of the functionally diverse amidohydrolase superfamily, is a homologue of LigI that catalyzes the hydrolysis of 2-pyrone-4,6-dicarboxylate ...[more]
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