Ontology highlight
ABSTRACT:
SUBMITTER: Delaney JT
PROVIDER: S-EPMC3977588 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Delaney Jessica T JT Muhammad Raafia R Shi Yaping Y Schildcrout Jonathan S JS Blair Marcia M Short Laura L Roden Dan M DM Darbar Dawood D
Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology 20130926 4
<h4>Aims</h4>SCN10A encodes the sodium channel Nav1.8 implicated by genome-wide association studies as a modulator of atrioventricular conduction (PR interval). In a cohort of patients with atrial fibrillation (AF), we examined whether there was an association between common variants in SCN10A and both the PR interval during normal sinus rhythm and the heart rate response during AF.<h4>Methods and results</h4>Patients prospectively enrolled in the Vanderbilt AF registry with electrocardiograms i ...[more]