Rational considerations about development of live attenuated Yersinia pestis vaccines.
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ABSTRACT:
SUBMITTER: Sun W
PROVIDER: S-EPMC3977779 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
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Rational considerations about development of live attenuated Yersinia pestis vaccines.
Current pharmaceutical biotechnology 20130101 10
The risk of plague as a bioweapon has prompted increasing research efforts to develop plague vaccines due to its extreme virulence and the ease of its transmission. Subunit vaccines that contain F1 and LcrV antigens of Y. pestis have been tested for safety and immunogenicity, but doubts have been raised about whether subunit vaccines that engender antibody responses will protect against pneumonic plague, which requires both humeral and cellular immune responses for protection. The live, attenuat ...[more]
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