Ontology highlight
ABSTRACT:
SUBMITTER: Haase N
PROVIDER: S-EPMC3977876 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Haase Nadine N Rugor Julianna J Przybyl Lukasz L Qadri Fatimunnisa F Müller Dominik N DN Dechend Ralf R
PloS one 20140407 4
Relaxin is a corpus-luteum produced protein hormone with vasodilatatory, anti-fibrotic, and angiogenic properties that are opposite to angiotensin (Ang) II. We investigated whether or not relaxin ameliorates Ang II-induced target-organ damage. We used double transgenic rats harboring both human renin and angiotensinogen genes (dTGR) that develop severe hypertension, target-organ damage, and die untreated within 7-8 weeks. Recombinant relaxin at a low (26 μg/kg/d) and a high dose (240 μg/kg/d) wa ...[more]