Dataset Information

XPF-673C>T polymorphism effect on the susceptibility to esophageal cancer in Chinese population.

ABSTRACT: PURPOSE:Xeroderma pigmentsum group F (XPF) plays a pivotal role in DNA nucleotide excision repair and has been linked to the development of various cancers. This study aims to assess the association of XPF genetic variants with the susceptibility to esophageal squamous cell carcinoma (ESCC) in Chinese population. METHODS:This two-stage case-control study was conducted in a total of 1524 patients with ESCC and 1524 controls. Genotype of XPF -673C>T and 11985A>G variants were determined by polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). Logistic regression analysis was performed to estimate odd ratios (ORs) and 95% confidence intervals (95% CI). RESULTS:Our case-control study showed that XPF -673TT genotype was associated with a decreased risk of ESCC compared with CC genotype in both case-control sets (Tangshan set: OR?=?0.58; 95%CI?=?0.34-0.99, P?=?0.040; Beijing set: OR?=?0.66; 95%CI?=?0.46-0.95, P?=?0.027). Stratified analyses revealed that a multiplicative interaction between -673C>T variant and age, sex or smoking status was evident (Gene-age: Pinteraction?=?0.002; Gene-sex: Pinteraction?=?0.002; Gene-smoking: Pinteraction?=?0.002). For XPF 11985A>G polymorphism, there was no significant difference of genotype distribution between ESCC cases and controls. CONCLUSION:These findings indicated that genetic variants in XPF might contribute to the susceptibility to ESCC.

SUBMITTER: Liu Y

PROVIDER: S-EPMC3978021 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

XPF-673C>T polymorphism effect on the susceptibility to esophageal cancer in Chinese population.

Liu Yingwen Y Cao Lei L Chang Jiang J Lin Jia J He Bing B Rao Juan J Zhang Zhi Z Zhang Xuemei X

PloS one 20140407 4

<h4>Purpose</h4>Xeroderma pigmentsum group F (XPF) plays a pivotal role in DNA nucleotide excision repair and has been linked to the development of various cancers. This study aims to assess the association of XPF genetic variants with the susceptibility to esophageal squamous cell carcinoma (ESCC) in Chinese population.<h4>Methods</h4>This two-stage case-control study was conducted in a total of 1524 patients with ESCC and 1524 controls. Genotype of XPF -673C>T and 11985A>G variants were determ ...[more]

PMID: 24709955

Similar Datasets

Project description:AimTo investigate the association between colorectal cancer (CRC) genetic susceptibility variants and esophageal cancer in a Chinese Han population.MethodsA case-control study was conducted including 360 esophageal cancer patients and 310 healthy controls. Thirty-one single-nucleotide polymorphisms (SNPs) associated with CRC risk from previous genome-wide association studies were analyzed. SNPs were genotyped using Sequenom Mass-ARRAY technology, and genotypic frequencies in controls were tested for departure from Hardy-Weinberg equilibrium using a Fisher's exact test. The allelic frequencies were compared between cases and controls using a χ(2) test. Associations between the SNPs and the risk of esophageal cancer were tested using various genetic models (codominant, dominant, recessive, overdominant, and additive). ORs and 95%CIs were calculated by unconditional logistic regression with adjustments for age and sex.ResultsThe minor alleles of rs1321311 and rs4444235 were associated with a 1.53-fold (95%CI: 1.15-2.06; P = 0.004) and 1.28-fold (95%CI: 1.03-1.60; P = 0.028) increased risk of esophageal cancer in the allelic model analysis, respectively. In the genetic model analysis, the C/C genotype of rs3802842 was associated with a reduced risk of esophageal cancer in the codominant model (OR = 0.52, 95%CI: 0.31-0.88; P = 0.033) and recessive model (OR = 0.55, 95%CI: 0.34-0.87; P = 0.010). The rs4939827 C/T-T/T genotype was associated with a 0.67-fold (95%CI: 0.46-0.98; P = 0.038) decreased esophageal cancer risk under the dominant model. In addition, rs6687758, rs1321311, and rs4444235 were associated with an increased risk. In particular, the T/T genotype of rs1321311 was associated with an 8.06-fold (95%CI: 1.96-33.07; P = 0.004) increased risk in the codominant model.ConclusionThese results provide evidence that known genetic variants associated with CRC risk confer risk for esophageal cancer, and may bring risk for other digestive system tumors.

Dataset Information

XPF-673C>T polymorphism effect on the susceptibility to esophageal cancer in Chinese population.

Publications

XPF-673C>T polymorphism effect on the susceptibility to esophageal cancer in Chinese population.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets