Ontology highlight
ABSTRACT:
SUBMITTER: Dehe PM
PROVIDER: S-EPMC3978046 | biostudies-literature | 2013 May
REPOSITORIES: biostudies-literature
Dehé Pierre-Marie PM Coulon Stéphane S Scaglione Sarah S Shanahan Paul P Takedachi Arato A Wohlschlegel James A JA Yates John R JR Llorente Bertrand B Russell Paul P Gaillard Pierre-Henri L PH
Nature structural & molecular biology 20130414 5
Structure-specific DNA endonucleases have critical roles during DNA replication, repair and recombination, yet they also have the potential for causing genome instability. Controlling these enzymes may be essential to ensure efficient processing of ad hoc substrates and to prevent random, unscheduled processing of other DNA structures, but it is unknown whether structure-specific endonucleases are regulated in response to DNA damage. Here, we uncover DNA damage-induced activation of Mus81-Eme1 H ...[more]