T cell-derived interleukin (IL)-21 promotes brain injury following stroke in mice.
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ABSTRACT:
SUBMITTER: Clarkson BD
PROVIDER: S-EPMC3978271 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
T cell-derived interleukin (IL)-21 promotes brain injury following stroke in mice.
Clarkson Benjamin D S BD Ling Changying C Shi Yejie Y Harris Melissa G MG Rayasam Aditya A Sun Dandan D Salamat M Shahriar MS Kuchroo Vijay V Lambris John D JD Sandor Matyas M Fabry Zsuzsanna Z
The Journal of experimental medicine 20140310 4
T lymphocytes are key contributors to the acute phase of cerebral ischemia reperfusion injury, but the relevant T cell-derived mediators of tissue injury remain unknown. Using a mouse model of transient focal brain ischemia, we report that IL-21 is highly up-regulated in the injured mouse brain after cerebral ischemia. IL-21-deficient mice have smaller infarcts, improved neurological function, and reduced lymphocyte accumulation in the brain within 24 h of reperfusion. Intracellular cytokine sta ...[more]
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