Ontology highlight
ABSTRACT:
SUBMITTER: Takayanagi M
PROVIDER: S-EPMC3978498 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Takayanagi Masayoshi M Kurisaki Ikuo I Nagaoka Masataka M
Scientific reports 20140408
Protein allostery is essential for vital activities. Allosteric regulation of human hemoglobin (HbA) with two quaternary states T and R has been a paradigm of allosteric structural regulation of proteins. It is widely accepted that oxygen molecules (O2) act as a "site-specific" homotropic effector, or the successive O2 binding to the heme brings about the quaternary regulation. However, here we show that the site-specific allosteric effect is not necessarily only a unique mechanism of O2 alloste ...[more]