Ontology highlight
ABSTRACT:
SUBMITTER: Chami N
PROVIDER: S-EPMC3978511 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Genes 20140127 1
Genome-wide association studies (GWAS) have identified reproducible genetic associations with hundreds of human diseases and traits. The vast majority of these associated single nucleotide polymorphisms (SNPs) are non-coding, highlighting the challenge in moving from genetic findings to mechanistic and functional insights. Nevertheless, large-scale (epi)genomic studies and bioinformatic analyses strongly suggest that GWAS hits are not randomly distributed in the genome but rather pinpoint specif ...[more]