Dataset Information

Remission in rheumatoid arthritis: benefit over low disease activity in patient-reported outcomes and costs.

ABSTRACT:

Introduction

Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes a considerable burden for the patient and society. It is not clear yet whether aiming for remission (REM) is worthwhile, especially when compared with low disease activity (LDA).

Methods

In 356 consecutive RA patients, we obtained data on physical function (health assessment questionnaire (HAQ)), health-related quality of life (HRQoL: Short Form 36 (SF36), Short Form 6 dimensions (SF-6D), Euro QoL 5D (EQ-5D)), work productivity (work productivity and activity impairment questionnaire (WPAI)), as well as estimation of direct and indirect costs. Cross-sectionally, data were compared in patients within different levels of disease activity according to the simplified disease activity index (SDAI; remission (REM ?3.3); n?=?87; low disease activity (LDA: 3.3?11 n?=?119) by using analyses of variance (ANOVA). Longitudinal investigations assessed patients who changed from LDA to REM and vice versa.

Results

We found differences in patients achieving REM compared with LDA for HAQ (0.39?±?0.58 versus 0.72?±?68), WPAI (percentage impairment while working 11.8%?±?18.7% versus 26.8%?±?23.9%; percentage of overall activity impairment, 10.8%?±?14.1% versus 29.0%?±?23.6%)), EQ-5D (0.89?±?0.12 versus 0.78?±?0.6) and SF-36 (physical component score (PCS): 46.0?±?8.6 versus 38.3?±?10.5; mental component score (MCS): 49.9?±?11.1 versus 47.9?±?12.3) (P?ConclusionPatients with REM show better function, HRQoL, and productivity, even when compared with another good state, such as LDA. Also from a cost perspective, REM appears superior to all other states.

SUBMITTER: Radner H

PROVIDER: S-EPMC3979137 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature

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Remission in rheumatoid arthritis: benefit over low disease activity in patient-reported outcomes and costs.

Radner Helga H Smolen Josef S JS Aletaha Daniel D

Arthritis research & therapy 20140221 1

<h4>Introduction</h4>Rheumatoid arthritis (RA) is a chronic inflammatory disease that causes a considerable burden for the patient and society. It is not clear yet whether aiming for remission (REM) is worthwhile, especially when compared with low disease activity (LDA).<h4>Methods</h4>In 356 consecutive RA patients, we obtained data on physical function (health assessment questionnaire (HAQ)), health-related quality of life (HRQoL: Short Form 36 (SF36), Short Form 6 dimensions (SF-6D), Euro QoL ...[more]

PMID: 24555808

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Dataset Information

Remission in rheumatoid arthritis: benefit over low disease activity in patient-reported outcomes and costs.

Introduction

Methods

Results

Publications

Remission in rheumatoid arthritis: benefit over low disease activity in patient-reported outcomes and costs.

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