An efficient and practical radiosynthesis of [11C]temozolomide.
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ABSTRACT:
SUBMITTER: Moseley CK
PROVIDER: S-EPMC3979304 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
An efficient and practical radiosynthesis of [11C]temozolomide.
Moseley Christian K CK Carlin Stephen M SM Neelamegam Ramesh R Hooker Jacob M JM
Organic letters 20121114 23
Temozolomide (TMZ) is a prodrug for an alkylating agent used for the treatment of malignant brain tumors. A positron emitting version, [(11)C]TMZ, has been utilized to help elucidate the mechanism and biodistribution of TMZ. Challenges in [(11)C]TMZ synthesis and reformulation make it difficult for routine production. A highly reproducible one-pot radiosynthesis of [(11)C]TMZ with a radiochemical yield of 17 ± 5% and ≥97% radiochemical purity is reported. ...[more]
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