Ontology highlight
ABSTRACT:
SUBMITTER: Wang T
PROVIDER: S-EPMC3979666 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Wang Tao T Chen Beibei B Kim MinSoo M Xie Yang Y Xiao Guanghua G
PloS one 20140408 4
Cross-linking immunoprecipitation coupled with high-throughput sequencing (CLIP-Seq) has made it possible to identify the targeting sites of RNA-binding proteins in various cell culture systems and tissue types on a genome-wide scale. Here we present a novel model-based approach (MiClip) to identify high-confidence protein-RNA binding sites from CLIP-seq datasets. This approach assigns a probability score for each potential binding site to help prioritize subsequent validation experiments. The M ...[more]