Ontology highlight
ABSTRACT:
SUBMITTER: Sardanyes J
PROVIDER: S-EPMC3980229 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Sardanyés Josep J Simó Carles C Martínez Regina R Solé Ricard V RV Elena Santiago F SF
Scientific reports 20140409
The distribution of mutational fitness effects (DMFE) is crucial to the evolutionary fate of quasispecies. In this article we analyze the effect of the DMFE on the dynamics of a large quasispecies by means of a phenotypic version of the classic Eigen's model that incorporates beneficial, neutral, deleterious, and lethal mutations. By parameterizing the model with available experimental data on the DMFE of Vesicular stomatitis virus (VSV) and Tobacco etch virus (TEV), we found that increasing mut ...[more]