Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium.
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ABSTRACT:
SUBMITTER: Coureuil M
PROVIDER: S-EPMC3980637 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Publications
Meningococcal type IV pili recruit the polarity complex to cross the brain endothelium.
Coureuil Mathieu M Mikaty Guillain G Miller Florence F Lécuyer Hervé H Bernard Christine C Bourdoulous Sandrine S Duménil Guillaume G Mège René-Marc RM Weksler Babette B BB Romero Ignacio A IA Couraud Pierre-Olivier PO Nassif Xavier X
Science (New York, N.Y.) 20090611 5936
Type IV pili mediate the initial interaction of many bacterial pathogens with their host cells. In Neisseria meningitidis, the causative agent of cerebrospinal meningitis, type IV pili-mediated adhesion to brain endothelial cells is required for bacteria to cross the blood-brain barrier. Here, type IV pili-mediated adhesion of N. meningitidis to human brain endothelial cells was found to recruit the Par3/Par6/PKCzeta polarity complex that plays a pivotal role in the establishment of eukaryotic c ...[more]
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