Ontology highlight
ABSTRACT:
SUBMITTER: Mezquita B
PROVIDER: S-EPMC3980740 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Mezquita Belén B Mezquita Pau P Pau Montserrat M Mezquita Jovita J Mezquita Cristóbal C
Cells 20140214 1
One of the best examples of the renaissance of Src as an open door to cancer has been the demonstration that just five min of Src activation is sufficient for transformation and also for induction and maintenance of cancer stem cells [1]. Many tyrosine kinase receptors, through the binding of their ligands, become the keys that unlock the structure of Src and activate its oncogenic transduction pathways. Furthermore, intracellular isoforms of these receptors, devoid of any tyrosine kinase activi ...[more]