Ontology highlight
ABSTRACT:
SUBMITTER: Johnson MA
PROVIDER: S-EPMC3981720 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Johnson Mark A MA Vidoni Sara S Durigon Romina R Pearce Sarah F SF Rorbach Joanna J He Jiuya J Brea-Calvo Gloria G Minczuk Michal M Reyes Aurelio A Holt Ian J IJ Spinazzola Antonella A
PloS one 20140409 4
Amino acids are essential for cell growth and proliferation for they can serve as precursors of protein synthesis, be remodelled for nucleotide and fat biosynthesis, or be burnt as fuel. Mitochondria are energy producing organelles that additionally play a central role in amino acid homeostasis. One might expect mitochondrial metabolism to be geared towards the production and preservation of amino acids when cells are deprived of an exogenous supply. On the contrary, we find that human cells res ...[more]