Ontology highlight
ABSTRACT:
SUBMITTER: Mouw JK
PROVIDER: S-EPMC3981899 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Mouw Janna K JK Yui Yoshihiro Y Damiano Laura L Bainer Russell O RO Lakins Johnathon N JN Acerbi Irene I Ou Guanqing G Wijekoon Amanda C AC Levental Kandice R KR Gilbert Penney M PM Hwang E Shelley ES Chen Yunn-Yi YY Weaver Valerie M VM
Nature medicine 20140316 4
Tissue mechanics regulate development and homeostasis and are consistently modified in tumor progression. Nevertheless, the fundamental molecular mechanisms through which altered mechanics regulate tissue behavior and the clinical relevance of these changes remain unclear. We demonstrate that increased matrix stiffness modulates microRNA expression to drive tumor progression through integrin activation of β-catenin and MYC. Specifically, in human and mouse tissue, increased matrix stiffness indu ...[more]