Ontology highlight
ABSTRACT:
SUBMITTER: Bohara M
PROVIDER: S-EPMC3982079 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Bohara Manoj M Kambe Yuki Y Nagayama Tetsuya T Tokimura Hiroshi H Arita Kazunori K Miyata Atsuro A
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20140108 4
C-type natriuretic peptide (CNP) is abundant in brain and is reported to exert autocrine function in vascular cells, but its effect on blood-brain barrier (BBB) permeability has not been clarified yet. Here, we examined this effect. Transendothelial electrical resistance (TEER) of in vitro BBB model, composed of bovine brain microvascular endothelial cells and astrocytes, was significantly dose dependently decreased by CNP (1, 10, and 100 nmol/L). C-type natriuretic peptide treatment reduced bot ...[more]