Ontology highlight
ABSTRACT:
SUBMITTER: Lu Z
PROVIDER: S-EPMC3982150 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Lu Zhonglei Z Bauzon Frederick F Fu Hao H Cui Jinhua J Zhao Hongling H Nakayama Keiko K Nakayama Keiich I KI Zhu Liang L
Nature communications 20140317
One mechanism of tumour suppression by pRb is repressing E2F1. Hence, E2f1 deletion diminishes tumorigenesis following Rb1 loss. However, E2F1 promotes both proliferation and apoptosis. It therefore remains unclear how de-repressed E2F1 promotes tumorigenesis. Another mechanism of pRb function is repressing Skp2 to elevate p27 to arrest proliferation. However, Skp2 deletion induced apoptosis, not proliferation arrest, in Rb1-deficient pituitary tumorigenesis. Here we show that Rb1 deletion induc ...[more]