Degradation of centromeric histone H3 variant Cse4 requires the Fpr3 peptidyl-prolyl Cis-Trans isomerase.
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ABSTRACT:
SUBMITTER: Ohkuni K
PROVIDER: S-EPMC3982699 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
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Degradation of centromeric histone H3 variant Cse4 requires the Fpr3 peptidyl-prolyl Cis-Trans isomerase.
Ohkuni Kentaro K Abdulle Rashid R Kitagawa Katsumi K
Genetics 20140210 4
The centromeric histone H3 variant Cse4 in Saccharomyces cerevisiae is polyubiquitylated and degraded in a proteasome-dependent manner. We report here that the proline isomerase Fpr3 regulates Cse4 proteolysis. Structural change in Cse4 by Fpr3 might be important for the interaction between Cse4 and the E3 ubiquitin ligase Psh1. ...[more]
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