WIDE AWAKE mediates the circadian timing of sleep onset.
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ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC3982794 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
WIDE AWAKE mediates the circadian timing of sleep onset.
Liu Sha S Lamaze Angelique A Liu Qili Q Tabuchi Masashi M Yang Yong Y Fowler Melissa M Bharadwaj Rajnish R Zhang Julia J Bedont Joseph J Blackshaw Seth S Lloyd Thomas E TE Montell Craig C Sehgal Amita A Koh Kyunghee K Wu Mark N MN
Neuron 20140313 1
How the circadian clock regulates the timing of sleep is poorly understood. Here, we identify a Drosophila mutant, wide awake (wake), that exhibits a marked delay in sleep onset at dusk. Loss of WAKE in a set of arousal-promoting clock neurons, the large ventrolateral neurons (l-LNvs), impairs sleep onset. WAKE levels cycle, peaking near dusk, and the expression of WAKE in l-LNvs is Clock dependent. Strikingly, Clock and cycle mutants also exhibit a profound delay in sleep onset, which can be re ...[more]
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