Ontology highlight
ABSTRACT:
SUBMITTER: Zong FY
PROVIDER: S-EPMC3983035 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Zong Feng-Yang FY Fu Xing X Wei Wen-Juan WJ Luo Ya-Ge YG Heiner Monika M Cao Li-Juan LJ Fang Zhaoyuan Z Fang Rong R Lu Daru D Ji Hongbin H Hui Jingyi J
PLoS genetics 20140410 4
Lung cancer is the leading cause of cancer-related death worldwide. Aberrant splicing has been implicated in lung tumorigenesis. However, the functional links between splicing regulation and lung cancer are not well understood. Here we identify the RNA-binding protein QKI as a key regulator of alternative splicing in lung cancer. We show that QKI is frequently down-regulated in lung cancer, and its down-regulation is significantly associated with a poorer prognosis. QKI-5 inhibits the proliferat ...[more]