Toroidal-spiral particles for codelivery of anti-VEGFR-2 antibody and irinotecan: a potential implant to hinder recurrence of glioblastoma multiforme.
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ABSTRACT:
SUBMITTER: Sharma V
PROVIDER: S-EPMC3983134 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
Toroidal-spiral particles for codelivery of anti-VEGFR-2 antibody and irinotecan: a potential implant to hinder recurrence of glioblastoma multiforme.
Sharma Vishal V Köllmer Melanie M Szymusiak Magdalena M Nitsche Ludwig C LC Gemeinhart Richard A RA Liu Ying Y
Biomacromolecules 20140211 3
Heterogeneous toroidal-spiral particles (TSPs) were generated by polymer droplet sedimentation, interaction, and cross-linking. TSPs provide a platform for encapsulation and release of multiple compounds of different sizes and physicochemical properties. As a model system, we demonstrate the encapsulation and independently controlled release of an anti-VEGFR-2 antibody and irinotecan for the treatment of glioblastoma multiforme. The anti-VEGFR-2 antibody was released from the TS channels and its ...[more]
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