Ontology highlight
ABSTRACT:
SUBMITTER: Chen CY
PROVIDER: S-EPMC3983378 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Chen Chi-Yuan CY Yang Shuenn-Chen SC Lee Kuo-Hsiung KH Yang Xiaoming X Wei Lin-Yi LY Chow Lu-Ping LP Wang Tzu-Chien V TC Hong Tse-Ming TM Lin Jau-Chen JC Kuan Crysline C Yang Pan-Chyr PC
Journal of medicinal chemistry 20140131 3
Natural products are the major sources of currently available anticancer drugs. We recently reported that phenanthrene-based tylophorine derivative-1 (PBT-1) may be a potential antitumor agent for lung adenocarcinoma. We therefore examined the direct targets of PBT-1 and their effects in inhibiting lung adenocarcinoma. We found that PBT-1 reduced the level of Slug and inhibits the migration, invasion, and filopodia formation of lung adenocarcinoma CL1-5 cells in vitro. In addition, PBT-1 display ...[more]