Ontology highlight
ABSTRACT:
SUBMITTER: Wang XF
PROVIDER: S-EPMC3983391 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Wang Xiao-Feng XF Guan Fang F Ohkoshi Emika E Guo Wanjun W Wang Lili L Zhu Dong-Qing DQ Wang Sheng-Biao SB Wang Li-Ting LT Hamel Ernest E Yang Dexuan D Li Linna L Qian Keduo K Morris-Natschke Susan L SL Yuan Shoujun S Lee Kuo-Hsiung KH Xie Lan L
Journal of medicinal chemistry 20140206 4
The 6-methoxy-1,2,3,4-tetrahydroquinoline moiety in prior leads 2-chloro- and 2-methyl-4-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)quinazoline (1a and 1b) was modified to produce 4-(N-cycloamino)quinazolines (4a-c and 5a-m). The new compounds were evaluated in cytotoxicity and tubulin inhibition assays, resulting in the discovery of new tubulin-polymerization inhibitors. 7-Methoxy-4-(2-methylquinazolin-4-yl)-3,4-dihydroquinoxalin- 2(1H)-one (5f), the most potent compound, exhibited high in vitro c ...[more]