Utility of gene expression profiling score variability to predict clinical events in heart transplant recipients.

ABSTRACT:

Background

Gene expression profiling test scores have primarily been used to identify heart transplant recipients who have a low probability of rejection at the time of surveillance testing. We hypothesized that the variability of gene expression profiling test scores within a patient may predict risk of future events of allograft dysfunction or death.

Method

Patients from the IMAGE study with rejection surveillance gene expression profiling tests performed at 1- to 6-month intervals were selected for this cohort study. Gene expression profiling score variability was defined as the standard deviation of an individual's cumulative test scores. Gene expression profiling ordinal score (range, 0-39), threshold score (binary value=1 if ordinal score ≥ 34), and score variability w

SUBMITTER: Deng MC 

PROVIDER: S-EPMC3983476 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature