TP53 supports basal-like differentiation of mammary epithelial cells by preventing translocation of deltaNp63 into nucleoli.
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ABSTRACT:
SUBMITTER: Munne PM
PROVIDER: S-EPMC3983616 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
TP53 supports basal-like differentiation of mammary epithelial cells by preventing translocation of deltaNp63 into nucleoli.
Munne Pauliina M PM Gu Yuexi Y Tumiati Manuela M Gao Ping P Koopal Sonja S Uusivirta Sanna S Sawicki Janet J Wei Gong-Hong GH Kuznetsov Sergey G SG
Scientific reports 20140411
Multiple observations suggest a cell type-specific role for TP53 in mammary epithelia. We developed an in vitro assay, in which primary mouse mammary epithelial cells (mMECs) progressed from lumenal to basal-like phenotypes based on expression of Krt18 or ΔNp63, respectively. Such transition was markedly delayed in Trp53(-/-) mMECs suggesting that Trp53 is required for specification of the basal, but not lumenal cells. Evidence from human basal-like cell lines suggests that TP53 may support the ...[more]
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