Ontology highlight
ABSTRACT:
SUBMITTER: Klco JM
PROVIDER: S-EPMC3983786 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Klco Jeffery M JM Spencer David H DH Miller Christopher A CA Griffith Malachi M Lamprecht Tamara L TL O'Laughlin Michelle M Fronick Catrina C Magrini Vincent V Demeter Ryan T RT Fulton Robert S RS Eades William C WC Link Daniel C DC Graubert Timothy A TA Walter Matthew J MJ Mardis Elaine R ER Dipersio John F JF Wilson Richard K RK Ley Timothy J TJ
Cancer cell 20140306 3
The relationships between clonal architecture and functional heterogeneity in acute myeloid leukemia (AML) samples are not yet clear. We used targeted sequencing to track AML subclones identified by whole-genome sequencing using a variety of experimental approaches. We found that virtually all AML subclones trafficked from the marrow to the peripheral blood, but some were enriched in specific cell populations. Subclones showed variable engraftment potential in immunodeficient mice. Xenografts we ...[more]