Ontology highlight
ABSTRACT:
SUBMITTER: Fan J
PROVIDER: S-EPMC3983872 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Fan Jianqing J Han Xu X Gu Weijie W
Journal of the American Statistical Association 20120101 499
Multiple hypothesis testing is a fundamental problem in high dimensional inference, with wide applications in many scientific fields. In genome-wide association studies, tens of thousands of tests are performed simultaneously to find if any SNPs are associated with some traits and those tests are correlated. When test statistics are correlated, false discovery control becomes very challenging under arbitrary dependence. In the current paper, we propose a novel method based on principal factor ap ...[more]