Insulin levels and HOMA index are associated with exercise capacity in patients with type 2 diabetes and coronary artery disease.

ABSTRACT: BACKGROUND:Previous studies on type 2 diabetes have shown an association between exercise capacity and insulin resistance. In patients with coronary artery disease (CAD) exercise capacity is often reduced due to exercise-induced ischemia. We have investigated the association between glucometabolic control, including the homeostatic model assessment (HOMA) of insulin resistance, and exercise capacity in patients with type 2 diabetes and CAD with and without exercise-induced ischemia. METHODS:In 137 patients (age 63.1?±?7.9) cardiopulmonary exercise testing on treadmill was performed using a modified Balke protocol. The highest oxygen uptake (VO2peak) was reported as 30-s average. Fasting blood samples were drawn for determination of glucose, insulin and HbA1c. Insulin resistance (IR) was assessed by the HOMA2-IR computer model. Exercise-induced ischemia was defined as angina and/ or ST-depression in ECG???0.1 mV during the exercise test. RESULTS:HOMA2-IR was inversely correlated to VO2peak (r?=?-0.328, p?

SUBMITTER: Byrkjeland R 

PROVIDER: S-EPMC3984726 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature