Dataset Information

Correlations between MRI and Information Processing Speed in MS: A Meta-Analysis.

ABSTRACT: Objectives. To examine relationships between conventional MRI measures and the paced auditory serial addition test (PASAT) and symbol digit modalities test (SDMT). Methods. A systematic literature review was conducted. Included studies had ?30 multiple sclerosis (MS) patients, administered the SDMT or PASAT, and measured T2LV or brain atrophy. Meta-analysis of MRI/information processing speed (IPS) correlations, analysis of MRI/IPS significance tests to account for reporting bias, and binomial testing to detect trends when comparing correlation strengths of SDMT versus PASAT and T2LV versus atrophy were conducted. Results. The 39 studies identified frequently reported only significant correlations, suggesting reporting bias. Direct meta-analysis was only feasible for correlations between SDMT and T2LV (r = -0.45, P < 0.001) and atrophy in patients with mixed-MS subtypes (r = -0.54, P < 0.001). Familywise Holm-Bonferroni testing found that selective reporting was not the source of at least half of significant results reported. Binomial tests (P = 0.006) favored SDMT over PASAT in strength of MRI correlations. Conclusions. A moderate-to-strong correlation exists between impaired IPS and MRI in mixed MS populations. Correlations with MRI were stronger for SDMT than for PASAT. Neither heterogeneity among populations nor reporting bias appeared to be responsible for these findings.

SUBMITTER: Rao SM

PROVIDER: S-EPMC3984845 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Correlations between MRI and Information Processing Speed in MS: A Meta-Analysis.

Rao S M SM Martin A L AL Huelin R R Wissinger E E Khankhel Z Z Kim E E Fahrbach K K

Multiple sclerosis international 20140325

Objectives. To examine relationships between conventional MRI measures and the paced auditory serial addition test (PASAT) and symbol digit modalities test (SDMT). Methods. A systematic literature review was conducted. Included studies had ≥30 multiple sclerosis (MS) patients, administered the SDMT or PASAT, and measured T2LV or brain atrophy. Meta-analysis of MRI/information processing speed (IPS) correlations, analysis of MRI/IPS significance tests to account for reporting bias, and binomial t ...[more]

PMID: 24795824

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Project description:Objectives The purpose of this study is to determine the associations between horizontal jump and sprint acceleration, as well as maximal speed performance. Methods A systematic literature search was performed using PubMed, MEDLINE (EBSCOhost), and Web of Science. The studies that were included in this review must meet the following criteria: (1) well-trained individuals over the age of 18 years old; (2) Pearson’s correlation coefficients between sprint time and horizontal jump distance were provided; (3) the sprint distance was limited to 0–100 m. The quality of the studies was assessed using a modified version of the Downs and Black Quality Index test. A random-effects model was used to determine the effect sizes, and heterogeneity between studies was examined using the Q statistic and I2. Results From the identified 2,815 studies, 27 studies were included in this study (two from reference lists). The sprint time of the sprint acceleration phase was moderately and negatively correlated with the standing long jump (r = − 0.45, z = 7.48, p < 0.001), single leg standing long jump (r = − 0.48, z = 3.49, p < 0.001) and horizontal drop jump distance (r = − 0.48, z = 3.49, p < 0.001), and was largely and negatively correlated with multiple jump distance (r = − 0.69, z = 6.02, p < 0.001). Out of five studies assessed the standing triple jump, three studies reported significant positive association with the sprint acceleration performance. The sprint time of maximal speed phase was very largely and negatively associated with standing long jump distance (r = − 0.73, z = 4.44, p < 0.001) and multiple jump distance (r = − 0.76, z = 6.86, p < 0.001). Conclusions This review indicates the moderate to very large associations between horizontal jump and sprint acceleration and maximal speed performance, and the highest magnitude of associations between them is found in the multiple jump. Moreover, compared to the sprint acceleration performance, there are greater associations between maximal speed performance and standing long jump and multiple jump distance.

Project description:BackgroundHyperglycemia is believed to be a risk factor for cognitive decline, but the longitudinal relationship between hyperglycemia and cognitive decline in the Japanese population is unclear. The present study aimed to clarify the association between blood glucose levels and information processing ability in middle-aged and older adults.MethodsThe subjects were 866 men and 815 women aged 40-79 years not taking medication for diabetes who participated in the first study wave (1997-2000) and then participated at least once in the subsequent six study waves (2000-2012) of the National Institute for Longevity Sciences-Longitudinal Study of Aging, Japan. Hemoglobin A1c (HbA1c) levels were categorized into four groups (< 5.6, 5.6 to < 6.0, 6.0 to < 6.5, ≥ 6.5%), and a mixed-effects model was used to evaluate the effects of the HbA1c level (four groups) on repeated measures of information processing speed. The models also included baseline age, body mass index, ethanol intake, smoking status, educational level, family income, and history of stroke, hypertension, heart disease, and dyslipidemia as covariates.ResultsMean (standard deviation) HbA1c and follow-up time in participants were 5.2 (0.5) % and 10.0 (3.6) years, respectively. A linear mixed model showed that the main effect of the four HbA1c groups on information processing ability was not significant in either men or women, but the interaction of HbA1c and time with information processing speed in the higher HbA1c level groups (≥ 6.5% group in men, 6.0 to < 6.5% and ≥ 6.5% groups in women) was significant compared to the lower HbA1c level (< 5.6%) group (P < 0.05). When the slope of information processing speed by HbA1c level at baseline was examined, the slope of information processing speed in the higher HbA1c level (≥ 6.5%) group was higher than in the lower HbA1c level (< 5.6%) group, both in men (- 0.31/year) and in women (- 0.30/year), as well as in women with an HbA1c level of 6.0 to < 6.5% (- 0.40/year).ConclusionsHigher baseline HbA1c was associated with greater subsequent decline in information processing ability in Japanese community dwellers, even with the pre-clinical HbA1c level (6.0 to < 6.5%) in women. The results suggest that good glycemic control or prevention of hyperglycemia may contribute to maintaining information processing ability.

Dataset Information

Correlations between MRI and Information Processing Speed in MS: A Meta-Analysis.

Publications

Correlations between MRI and Information Processing Speed in MS: A Meta-Analysis.

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