Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypes.

ABSTRACT: Blood pressure is a critical determinant of cardiovascular morbidity and mortality. It is affected by environmental factors, but has a strong heritable component. Despite recent large genome-wide association studies, few genetic risk factors for blood pressure have been identified. Epidemiological studies suggest associations between blood pressure and several diseases and traits, which may partly arise from a shared genetic basis (genetic pleiotropy). Using genome-wide association studies summary statistics and a genetic pleiotropy-informed conditional false discovery rate method, we systematically investigated genetic overlap between systolic blood pressure (SBP) and 12 comorbid traits and diseases. We found significant enrichment of single nucleotide polymorphisms associated with SBP as

SUBMITTER: Andreassen OA 

PROVIDER: S-EPMC3984909 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature