Ontology highlight
ABSTRACT:
SUBMITTER: Adelman JL
PROVIDER: S-EPMC3984995 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Adelman Joshua L JL Sheng Ying Y Choe Seungho S Abramson Jeff J Wright Ernest M EM Rosenberg John M JM Grabe Michael M
Biophysical journal 20140301 6
Sodium-glucose transporters (SGLTs) facilitate the movement of water across the cell membrane, playing a central role in cellular homeostasis. Here, we present a detailed analysis of the mechanism of water permeation through the inward-facing state of vSGLT based on nearly 10 μs of molecular dynamics simulations. These simulations reveal the transient formation of a continuous water channel through the transporter that permits water to permeate the protein. Trajectories in which spontaneous rele ...[more]