Ontology highlight
ABSTRACT:
SUBMITTER: Liu Q
PROVIDER: S-EPMC3985381 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Liu Qian Q Sun Jessica D JD Wang Jingli J Ahluwalia Dharmendra D Baker Amanda F AF Cranmer Lee D LD Ferraro Damien D Wang Yan Y Duan Jian-Xin JX Ammons W Steve WS Curd John G JG Matteucci Mark D MD Hart Charles P CP
Cancer chemotherapy and pharmacology 20120302 6
<h4>Purpose</h4>Subregional hypoxia is a common feature of tumors and is recognized as a limiting factor for the success of radiotherapy and chemotherapy. TH-302, a hypoxia-activated prodrug selectively targeting hypoxic regions of solid tumors, delivers a cytotoxic warhead to the tumor, while maintaining relatively low systemic toxicity. The antitumor activity, different dosing sequences, and dosing regimens of TH-302 in combination with commonly used conventional chemotherapeutics were investi ...[more]