Ontology highlight
ABSTRACT:
SUBMITTER: Zhou T
PROVIDER: S-EPMC3985390 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Zhou Tongqing T Zhu Jiang J Wu Xueling X Moquin Stephanie S Zhang Baoshan B Acharya Priyamvada P Georgiev Ivelin S IS Altae-Tran Han R HR Chuang Gwo-Yu GY Joyce M Gordon MG Kwon Young Do YD Longo Nancy S NS Louder Mark K MK Luongo Timothy T McKee Krisha K Schramm Chaim A CA Skinner Jeff J Yang Yongping Y Yang Zhongjia Z Zhang Zhenhai Z Zheng Anqi A Bonsignori Mattia M Haynes Barton F BF Scheid Johannes F JF Nussenzweig Michel C MC Simek Melissa M Burton Dennis R DR Koff Wayne C WC Mullikin James C JC Connors Mark M Shapiro Lawrence L Nabel Gary J GJ Mascola John R JR Kwong Peter D PD
Immunity 20130801 2
Antibodies of the VRC01 class neutralize HIV-1, arise in diverse HIV-1-infected donors, and are potential templates for an effective HIV-1 vaccine. However, the stochastic processes that generate repertoires in each individual of >10(12) antibodies make elicitation of specific antibodies uncertain. Here we determine the ontogeny of the VRC01 class by crystallography and next-generation sequencing. Despite antibody-sequence differences exceeding 50%, antibody-gp120 cocrystal structures reveal VRC ...[more]