Ontology highlight
ABSTRACT:
SUBMITTER: Temme JS
PROVIDER: S-EPMC3985446 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20140123 5
SELMA (SELection with Modified Aptamers) is a directed evolution method which can be used to develop DNA-supported clusters of carbohydrates in which the geometry of clustering is optimized for strong recognition by a lectin of interest. Herein, we report a modification of SELMA which results in glycoclusters which achieve dramatically stronger target recognition (100-fold) with dramatically fewer glycans (2-3-fold). Our first applications of SELMA yielded clusters of 5-10 oligomannose glycans w ...[more]