Shape matters in protein mobility within membranes.
Ontology highlight
ABSTRACT:
SUBMITTER: Quemeneur F
PROVIDER: S-EPMC3986167 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
Shape matters in protein mobility within membranes.
Quemeneur François F Sigurdsson Jon K JK Renner Marianne M Atzberger Paul J PJ Bassereau Patricia P Lacoste David D
Proceedings of the National Academy of Sciences of the United States of America 20140324 14
The lateral mobility of proteins within cell membranes is usually thought to be dependent on their size and modulated by local heterogeneities of the membrane. Experiments using single-particle tracking on reconstituted membranes demonstrate that protein diffusion is significantly influenced by the interplay of membrane curvature, membrane tension, and protein shape. We find that the curvature-coupled voltage-gated potassium channel (KvAP) undergoes a significant increase in protein mobility und ...[more]
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