Dataset Information

Cell-type-based model explaining coexpression patterns of genes in the brain.

ABSTRACT: Spatial patterns of gene expression in the vertebrate brain are not independent, as pairs of genes can exhibit complex patterns of coexpression. Two genes may be similarly expressed in one region, but differentially expressed in other regions. These correlations have been studied quantitatively, particularly for the Allen Atlas of the adult mouse brain, but their biological meaning remains obscure. We propose a simple model of the coexpression patterns in terms of spatial distributions of underlying cell types and establish its plausibility using independently measured cell-type-specific transcriptomes. The model allows us to predict the spatial distribution of cell types in the mouse brain.

SUBMITTER: Grange P

PROVIDER: S-EPMC3986204 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Cell-type-based model explaining coexpression patterns of genes in the brain.

Grange Pascal P Bohland Jason W JW Okaty Benjamin W BW Sugino Ken K Bokil Hemant H Nelson Sacha B SB Ng Lydia L Hawrylycz Michael M Mitra Partha P PP

Proceedings of the National Academy of Sciences of the United States of America 20140325 14

Spatial patterns of gene expression in the vertebrate brain are not independent, as pairs of genes can exhibit complex patterns of coexpression. Two genes may be similarly expressed in one region, but differentially expressed in other regions. These correlations have been studied quantitatively, particularly for the Allen Atlas of the adult mouse brain, but their biological meaning remains obscure. We propose a simple model of the coexpression patterns in terms of spatial distributions of underl ...[more]

PMID: 24706869

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Dataset Information

Cell-type-based model explaining coexpression patterns of genes in the brain.

Publications

Cell-type-based model explaining coexpression patterns of genes in the brain.

Similar Datasets

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