Subcellular connectivity underlies pathway-specific signaling in the nucleus accumbens.
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ABSTRACT:
SUBMITTER: MacAskill AF
PROVIDER: S-EPMC3986679 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
Subcellular connectivity underlies pathway-specific signaling in the nucleus accumbens.
MacAskill Andrew F AF Little Justin P JP Cassel John M JM Carter Adam G AG
Nature neuroscience 20121111 12
We found that medium spiny neurons (MSNs) in both the direct and indirect pathways of the mouse nucleus accumbens (NAc) receive inputs from the cortex, thalamus and hippocampus. However, hippocampal inputs were much weaker onto indirect MSNs, where they contacted small spines located in the distal dendrites. This selective targeting means that these inputs must be gated by subthreshold depolarization to trigger action potentials and influence NAc output. ...[more]
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