Ontology highlight
ABSTRACT:
SUBMITTER: Shimakami T
PROVIDER: S-EPMC3986704 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Shimakami Tetsuro T Honda Masao M Shirasaki Takayoshi T Takabatake Riuta R Liu Fanwei F Murai Kazuhisa K Shiomoto Takayuki T Funaki Masaya M Yamane Daisuke D Murakami Seishi S Lemon Stanley M SM Kaneko Shuichi S
Scientific reports 20140415
Clinical studies suggest that the oral acyclic retinoid Peretinoin may reduce the recurrence of hepatocellular carcinoma (HCC) following surgical ablation of primary tumours. Since hepatitis C virus (HCV) infection is a major cause of HCC, we assessed whether Peretinoin and other retinoids have any effect on HCV infection. For this purpose, we measured the effects of several retinoids on the replication of genotype 1a, 1b, and 2a HCV in vitro. Peretinoin inhibited RNA replication for all genotyp ...[more]