Incretin treatment and risk of pancreatitis in patients with type 2 diabetes mellitus: systematic review and meta-analysis of randomised and non-randomised studies.

ABSTRACT:

Objective

To investigate the risk of pancreatitis associated with the use of incretin-based treatments in patients with type 2 diabetes mellitus.

Design

Systematic review and meta-analysis.

Data sources

Medline, Embase, the Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov.

Eligibility criteria

Randomised and non-randomised controlled clinical trials, prospective or retrospective cohort studies, and case-control studies of treatment with glucagon-like peptide-1 (GLP-1) receptor agonists or dipeptidyl peptidase-4 (DPP-4) inhibitors in adults with type 2 diabetes mellitus compared with placebo, lifestyle modification, or active anti-diabetic drugs.

Data collection and analysis

Pairs of trained reviewers independently screened

SUBMITTER: Li L 

PROVIDER: S-EPMC3987051 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature