Ontology highlight
ABSTRACT:
SUBMITTER: Burnette DT
PROVIDER: S-EPMC3987145 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
The Journal of cell biology 20140407 1
How adherent and contractile systems coordinate to promote cell shape changes is unclear. Here, we define a counterbalanced adhesion/contraction model for cell shape control. Live-cell microscopy data showed a crucial role for a contractile meshwork at the top of the cell, which is composed of actin arcs and myosin IIA filaments. The contractile actin meshwork is organized like muscle sarcomeres, with repeating myosin II filaments separated by the actin bundling protein α-actinin, and is mechani ...[more]