Ontology highlight
ABSTRACT:
SUBMITTER: Szabon-Watola MI
PROVIDER: S-EPMC3987963 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Szabon-Watola Monika I MI Ulatowski Sarah V SV George Kathleen M KM Hayes Christina D CD Steiger Scott A SA Natale Nicholas R NR
Bioorganic & medicinal chemistry letters 20131204 1
Isoxazole-1,4-dihydropyridines (IDHPs) were tethered to fluorescent moieties using double activation via a lanthanide assisted Weinreb amidation. IDHP-fluorophore conjugate 3c exhibits the highest binding to date for IDHPs at the multidrug-resistance transporter (MDR-1), and IDHP-fluorophore conjugates 3c and 7 distribute selectively in SH-SY5Y cells. A homology model for IDHP binding at MDR-1 is presented which represents our current working hypothesis. ...[more]